5-(2-Ethoxy-4-fluorophenyl)-1,2,4-triazolo[1,5-a]pyrimidine
نویسندگان
چکیده
منابع مشابه
4 - Chloro - 6 - ethoxy - 2 - ( methylthio ) pyrimidine
4,6-Dichloro-2-(methylthio)pyrimidine (3) reacts with EtONa in EtOH, at ca. 20 ◦C, for 2 h, to give exclusively 4-chloro-6-ethoxy-2-(methylthio)pyrimidine (5) in 89% yield. The latter is presented as a useful multifunctionalised pyrimidine scaffold.
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The 2-[(4-fluorophenyl)sulfonyl]ethoxy carbonyl (Fsec) group for protection of hydroxyl groups has been designed, synthesized, and evaluated. Fsec-Cl was readily prepared in 91% yield over three steps and subsequently used to protect 4-fluorobenzyl alcohol in high yield. The Fsec group was cleaved from the resulting model compound under mild basic conditions e.g., 20% piperidine in DMF and was ...
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In this study, two new salicylideneaniline derivative compounds which are an isomer of each other have been synthesized and characterized by X-Ray Diffraction (XRD) technique, IR spectroscopy, and theoretical method. While (E)-4-(dihydroxyamino)-2-(((4-fluorophenyl)imino) methyl)phenol (1), crystalizes triclinic P-1 space group, (E)-4-(dihydroxyamino)-2-(((3-fluorophenyl)im...
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(R)-(1)-2-Amino-4-(4-fluorophenyl)-5-[1-[4-(4-fluorophenyl)-4oxobutyl]pyrrolidin-3-yl]thiazole (NRA0045), a novel thiazole derivative, has high affinities for the human cloned dopamine D4.2, D4.4 and D4.7 receptors, with Ki values of 2.54, 0.55 and 0.54 nM, respectively. NRA0045 is approximately 91-fold more potent at the dopamine D4.2 receptor, compared with human cloned dopamine D2L receptor....
متن کامل4-(2-{2-[2-(2-Nitro-1H-imidazol-1-yl)ethoxy]ethoxy}ethoxy)benzaldehyde
In the mol-ecule of the title compound, C(16)H(19)N(3)O(6), the imidazole ring is essentially planar [maximum deviation = 0.002 (2) Å] and forms a dihedral angle of 5.08 (14)° with the nitro group. In the crystal structure, adjacent mol-ecules are connected via inter-molecular C-H⋯O hydrogen bonds into columns parallel to the a axis.
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ژورنال
عنوان ژورنال: IUCrData
سال: 2016
ISSN: 2414-3146
DOI: 10.1107/s2414314616017703